Towards the North west of this region is the first ridge of the himalaya is a high desert region, similar to the Tibetan plateau. This area encompasses the arid valleys of upper Mugu, Dolpo and Limi- Humla as well as the Tibetan marginal, a smaller range of peaks averaging less than 6000 m. The moisture-laden rains of the monsoon drop all their rain on the south side of the mountains, leaving the Trans-Himalaya of karnali in permanent rain shadow, providing great options to trek during monsoon season This region also offers the best off the beaten treks in Nepal Himalayas.

While the river that flows along the province makes it a perfect spot to indulge in white water rafting, areas of spiritual, historical, and archaeological importance such as, Jumla, Surkhet, Dailekh fall under this province making Karnali province popular amongst the Hindu pilgrims and researchers. Some of the rarest Himalayan herbs with medicinal properties can be found around the region.